LXR target genes and their products. LXR regulates cholesterol (Chol) efflux, centripetal cholesterol transport, cholesterol excretion, and fatty acid biosynthesis by inducing multiple genes involved in lipid metabolism. Two products of these genes, ABCA1 and apoE, promote macrophage cholesterol efflux. Another LXR target, macrophage LPL, is activated by apoC-II, which is also regulated by LXR. Cholesteryl ester transfer protein (CETP) promotes transfer of HDL cholesteryl ester to VLDLs, which are taken up by the liver. In the liver, Cyp7α (cytochrome P450 7α) promotes cholesterol excretion by mediating conversion of cholesterol into bile acids. ABCG5 and ABCG8 facilitate hepatic and intestinal cholesterol excretion. LXR activates SREBP1c, regulating the expression of multiple lipogenic proteins, including FAS (fatty acid synthesis), which is also a direct target of LXR.