Piezo 1 activation facilitates cholangiocarcinoma metastasis via Hippo/YAP signaling axis
B Zhu, W Qian, C Han, T Bai, X Hou - Molecular Therapy-Nucleic Acids, 2021 - cell.com
B Zhu, W Qian, C Han, T Bai, X Hou
Molecular Therapy-Nucleic Acids, 2021•cell.comTumor metastasis is one of the major factors for the high mortality in cholangiocarcinoma
(CCA), but its underlying mechanisms are not fully understood. Here, we report that Piezo-
type mechanosensitive ion channel component 1 (Piezo 1) is detected to be significantly
upregulated in CCA tissues, which is linked to a poor prognosis in patients, suggesting that
Piezo 1 may act in a pro-metastatic role in CCA development. Piezo 1 is activated through
20% simulated physiological stretch, and deleting Piezo 1 impedes epithelial-to …
(CCA), but its underlying mechanisms are not fully understood. Here, we report that Piezo-
type mechanosensitive ion channel component 1 (Piezo 1) is detected to be significantly
upregulated in CCA tissues, which is linked to a poor prognosis in patients, suggesting that
Piezo 1 may act in a pro-metastatic role in CCA development. Piezo 1 is activated through
20% simulated physiological stretch, and deleting Piezo 1 impedes epithelial-to …
Tumor metastasis is one of the major factors for the high mortality in cholangiocarcinoma (CCA), but its underlying mechanisms are not fully understood. Here, we report that Piezo-type mechanosensitive ion channel component 1 (Piezo 1) is detected to be significantly upregulated in CCA tissues, which is linked to a poor prognosis in patients, suggesting that Piezo 1 may act in a pro-metastatic role in CCA development. Piezo 1 is activated through 20% simulated physiological stretch, and deleting Piezo 1 impedes epithelial-to-mesenchymal transition (EMT) of CCA cells, as well as impairing their metastatic capacity in vitro and in vivo. Mechanistically, the activation of Piezo 1 results in large amounts of Yes-associated protein 1 (YAP) translocated into the nucleus from the cytoplasm, and thus the motility of CCA cells is significantly increased. These findings indicate that mechanical stimulation induces Piezo 1 activation, which might be involved in CCA metastasis via the Hippo/YAP signaling axis. Therefore, Piezo 1 and its downstream effectors may be a novel therapeutic target for CCA treatment.
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