Validation of effective therapeutic targets for ADPKD using animal models
YM Woo, JY Ko, EJ Lee - Cystogenesis, 2016 - Springer
YM Woo, JY Ko, EJ Lee
Cystogenesis, 2016•SpringerVarious polycystic kidney disease (PKD) animal models including Pkd1-or Pkd2-deficient
mice have been developed and efficiently utilized to identify novel therapeutic targets as
well as elucidate multiple mechanisms of cyst formation in PKD. Based on several
successful in vivo studies, preclinical approaches using PKD animal models would shed
light on the development of potential therapeutic strategies for PKD. Here, we provide an
update on the current evidence obtained by the in vivo evaluation of PKD therapeutic …
mice have been developed and efficiently utilized to identify novel therapeutic targets as
well as elucidate multiple mechanisms of cyst formation in PKD. Based on several
successful in vivo studies, preclinical approaches using PKD animal models would shed
light on the development of potential therapeutic strategies for PKD. Here, we provide an
update on the current evidence obtained by the in vivo evaluation of PKD therapeutic …
Abstract
Various polycystic kidney disease (PKD) animal models including Pkd1- or Pkd2-deficient mice have been developed and efficiently utilized to identify novel therapeutic targets as well as elucidate multiple mechanisms of cyst formation in PKD. Based on several successful in vivo studies, preclinical approaches using PKD animal models would shed light on the development of potential therapeutic strategies for PKD. Here, we provide an update on the current evidence obtained by the in vivo evaluation of PKD therapeutic candidates and discuss the effect of therapeutic targets.
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