Cisplatin is an effective anticancer drug; however, cisplatin use often leads to nephrotoxicity,
which limits its clinical effectiveness. In this study, we determined the effect of
dichloroacetate, a novel anticancer agent, in a mouse model of cisplatin-induced AKI.
Pretreatment with dichloroacetate significantly attenuated the cisplatin-induced increase in
BUN and serum creatinine levels, renal tubular apoptosis, and oxidative stress. Additionally,
pretreatment with dichloroacetate accelerated tubular regeneration after cisplatin-induced …