A new class of reverse signaling costimulators belongs to the TNF family
M Sun, PJ Fink - The Journal of Immunology, 2007 - journals.aai.org
M Sun, PJ Fink
The Journal of Immunology, 2007•journals.aai.orgRecent evidence shows that many molecules of the TNF family serve as counter-receptors,
inducing costimulation through reverse signals in addition to delivering signals through their
respective TNF receptors. In this review, we will discuss this new class of costimulators with
a focus on the mechanism of costimulation transduced by reverse signaling through Fas
ligand.
inducing costimulation through reverse signals in addition to delivering signals through their
respective TNF receptors. In this review, we will discuss this new class of costimulators with
a focus on the mechanism of costimulation transduced by reverse signaling through Fas
ligand.
Abstract
Recent evidence shows that many molecules of the TNF family serve as counter-receptors, inducing costimulation through reverse signals in addition to delivering signals through their respective TNF receptors. In this review, we will discuss this new class of costimulators with a focus on the mechanism of costimulation transduced by reverse signaling through Fas ligand.
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