Effects of prostaglandin E2 on bone in mice in vivo
Q Gao, M Xu, CB Alander, S Choudhary… - Prostaglandins & Other …, 2009 - Elsevier
We have examined the effects of varying doses, schedules and routes of administration of
prostaglandin E2 (PGE2) on bone in mice. Male C57BL/6 mice treated with a high dose of
PGE2 (6mg/kg/d) showed decreased trabecular bone volume (BV/TV) by 14 d, indicating
increased bone resorption. However, there was also stimulation of bone formation at 14 d
after 3 d treatment with PGE2, since mineral apposition rate (MAR) and bone formation rate
(BFR/BS) were increased. In CD-1 male and female mice, PGE2 (3mg/kg, 2/wk for 4 wk) …
prostaglandin E2 (PGE2) on bone in mice. Male C57BL/6 mice treated with a high dose of
PGE2 (6mg/kg/d) showed decreased trabecular bone volume (BV/TV) by 14 d, indicating
increased bone resorption. However, there was also stimulation of bone formation at 14 d
after 3 d treatment with PGE2, since mineral apposition rate (MAR) and bone formation rate
(BFR/BS) were increased. In CD-1 male and female mice, PGE2 (3mg/kg, 2/wk for 4 wk) …
