Suppression of hepatitis B virus enhancer 1 and 2 by hepatitis C virus core protein
CG Schüttler, N Fiedler, K Schmidt, R Repp… - Journal of …, 2002 - Elsevier
Background/Aims: Epidemiological studies have shown that coinfection or superinfection
with hepatitis B virus (HBV) and C virus (HCV) frequently leads to the suppression of
hepatitis B virus replication. The mechanism of this phenomenon is still unclear. Shih et al.[J
Virol 1993; 67: 5823] reported a direct suppression of HBV replication by the core protein of
HCV. The target structure of HCV core protein in this system remained unclear. Methods: As
HCV core protein has been shown to influence expression from transcriptional elements, we …
with hepatitis B virus (HBV) and C virus (HCV) frequently leads to the suppression of
hepatitis B virus replication. The mechanism of this phenomenon is still unclear. Shih et al.[J
Virol 1993; 67: 5823] reported a direct suppression of HBV replication by the core protein of
HCV. The target structure of HCV core protein in this system remained unclear. Methods: As
HCV core protein has been shown to influence expression from transcriptional elements, we …
