Proteomic signature of acute liver failure: from discovery and verification in a pig model to confirmation in humans
J Wang, Z Sun, J Jiang, D Wu, X Liu, Z Xie… - Molecular & Cellular …, 2017 - ASBMB
Acute liver failure (ALF) is a fatal condition hallmarked by rapid development. The present
study aimed to describe the dynamic alterations of serum proteins associated with ALF
development, and to seek for novel biomarkers of ALF. Miniature pigs (n= 38) were
employed to establish ALF models by infusing d-galactosamine (GALN, 1.3 g/kg). A total of
1310 serum proteins were compared in pooled serum samples (n= 10) before and 36 h after
GALN administration through label-free quantitation (LFQ) based shotgun proteomics …
study aimed to describe the dynamic alterations of serum proteins associated with ALF
development, and to seek for novel biomarkers of ALF. Miniature pigs (n= 38) were
employed to establish ALF models by infusing d-galactosamine (GALN, 1.3 g/kg). A total of
1310 serum proteins were compared in pooled serum samples (n= 10) before and 36 h after
GALN administration through label-free quantitation (LFQ) based shotgun proteomics …
