Acute adaption to oral or intravenous phosphate requires parathyroid hormone
L Thomas, C Bettoni, T Knöpfel… - Journal of the …, 2017 - journals.lww.com
Phosphate (Pi) homeostasis is regulated by renal, intestinal, and endocrine mechanisms
through which Pi intake stimulates parathyroid hormone (PTH) and fibroblast growth factor-
23 secretion, increasing phosphaturia. Mechanisms underlying the early adaptive phase
and the role of the intestine, however, remain ill defined. We investigated mineral,
endocrine, and renal responses during the first 4 hours after intravenous and intragastric Pi
loading in rats. Intravenous Pi loading (0.5 mmol) caused a transient rise in plasma Pi levels …
through which Pi intake stimulates parathyroid hormone (PTH) and fibroblast growth factor-
23 secretion, increasing phosphaturia. Mechanisms underlying the early adaptive phase
and the role of the intestine, however, remain ill defined. We investigated mineral,
endocrine, and renal responses during the first 4 hours after intravenous and intragastric Pi
loading in rats. Intravenous Pi loading (0.5 mmol) caused a transient rise in plasma Pi levels …
