Mineralocorticoid receptor (MR), a hormone-activated transcription factor belonging to the
nuclear receptor superfamily, exerts widespread actions in many tissues such as tight
epithelia, the cardiovascular system, adipose tissues and macrophages. In the mammalian
brain, MR is present in the limbic areas where it is highly expressed in neurons of the
hippocampus and mostly absent in other regions while the glucocorticoid receptor (GR)
expression is ubiquitous. MR binds both aldosterone and glucocorticoids, the latter having a …