[HTML][HTML] Reconstitution and analysis of soluble inhibin and activin receptor complexes in a cell-free system
E del Re, Y Sidis, DA Fabrizio, HY Lin… - Journal of Biological …, 2004 - ASBMB
Activins and inhibins compose a heterogeneous subfamily within the transforming growth
factor-β (TGF-β) superfamily of growth and differentiation factors with critical biological
activities in embryos and adults. They signal through a heteromeric complex of type II, type I,
and for inhibin, type III receptors. To characterize the affinity, specificity, and activity of these
receptors (alone and in combination) for the inhibin/activin subfamily, we developed a cell-
free assay system using soluble receptor-Fc fusion proteins. The soluble activin type II …
factor-β (TGF-β) superfamily of growth and differentiation factors with critical biological
activities in embryos and adults. They signal through a heteromeric complex of type II, type I,
and for inhibin, type III receptors. To characterize the affinity, specificity, and activity of these
receptors (alone and in combination) for the inhibin/activin subfamily, we developed a cell-
free assay system using soluble receptor-Fc fusion proteins. The soluble activin type II …