[PDF][PDF] Bipolar cells use kainate and AMPA receptors to filter visual information into separate channels

SH DeVries - Neuron, 2000 - cell.com
SH DeVries
Neuron, 2000cell.com
Unlike cone photoreceptors, whose light responses have a uniform time course, retinal
ganglion cells are tuned to respond to different temporal components in a changing visual
scene. The signals in a mammalian cone flow to three to five morphologically distinct" OFF"
bipolar cells at a sign-conserving, glutamatergic synapse. By recording simultaneously from
pairs of synaptically connected cones and OFF bipolar cells, I now show that each
morphological type of OFF bipolar cell receives its signal through a different AMPA or …
Abstract
Unlike cone photoreceptors, whose light responses have a uniform time course, retinal ganglion cells are tuned to respond to different temporal components in a changing visual scene. The signals in a mammalian cone flow to three to five morphologically distinct "OFF" bipolar cells at a sign-conserving, glutamatergic synapse. By recording simultaneously from pairs of synaptically connected cones and OFF bipolar cells, I now show that each morphological type of OFF bipolar cell receives its signal through a different AMPA or kainate receptor. The characteristic rate at which each receptor recovers from desensitization divides the cone signal into temporal components. Temporal processing begins at the first synapse in the visual system.
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