In vitro and in vivo delivery of therapeutic proteins using cell penetrating peptides

A Bolhassani, BS Jafarzade, G Mardani - Peptides, 2017 - Elsevier
The failure of proteins to penetrate mammalian cells or target tumor cells restricts their value
as therapeutic tools in a variety of diseases such as cancers. Recently, protein transduction
domains (PTDs) or cell penetrating peptides (CPPs) have been shown to promote the
delivery of therapeutic proteins or peptides into live cells. The successful delivery of proteins
mainly depends on their physicochemical properties. Although, linear cell penetrating
peptides are one of the most effective delivery vehicles; but currently, cyclic CPPs has been …