Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

CE Tadokoro, G Shakhar, S Shen, Y Ding… - The Journal of …, 2006 - rupress.org
CE Tadokoro, G Shakhar, S Shen, Y Ding, AC Lino, A Maraver, JJ Lafaille, ML Dustin
The Journal of experimental medicine, 2006rupress.org
Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but
it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy
we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T
cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded
dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on
immune responses by attenuating the establishment of stable contacts during priming of …
Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs.
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