[HTML][HTML] Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARγ−/−, PPARδ−/−, PPARγδ−/−, or LXRαβ−/− bone marrow

C Marathe, MN Bradley, C Hong, L Chao, D Wilpitz… - Journal of lipid …, 2009 - ASBMB
Macrophage lipid metabolism and inflammatory responses are both regulated by the
nuclear receptors PPAR and LXR. Emerging links between inflammation and metabolic
disease progression suggest that PPAR and LXR signaling may alter macrophage function
and thereby impact systemic metabolism. In this study, the function of macrophage PPAR
and LXR in Th1-biased C57BL/6 mice was tested using a bone marrow transplantation
approach with PPARγ−/−, PPARδ−/−, PPARγδ−/−, and LXRαβ−/− cells. Despite their …