[HTML][HTML] Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes

H Fyrst, X Zhang, DR Herr, HS Byun, R Bittman… - Journal of lipid …, 2008 - ASBMB
Sphingolipids comprise a complex group of lipids concentrated in membrane rafts and
whose metabolites function as signaling molecules. Sphingolipids are conserved in
Drosophila, in which their tight regulation is required for proper development and tissue
integrity. In this study, we identified a new family of Drosophila sphingolipids containing two
double bonds in the long chain base (LCB). The lipids were found at low levels in wild-type
flies and accumulated markedly in Drosophila Sply mutants, which do not express …