IL-10-producing regulatory B cells are decreased in patients with psoriasis
M Hayashi, K Yanaba, Y Umezawa, Y Yoshihara… - Journal of …, 2016 - Elsevier
Abstract Backgrounds Interleukin (IL)-10-producing regulatory B cells (B10 cells) have been
shown to ameliorate psoriasis in mice. Human B10 progenitor cells are characterized as
CD19+ CD24 hi CD38 hi B cells that exert their regulatory functions via the production of IL-
10. However, the role of B10 cells in the pathogenesis of psoriasis remains unclear.
Objectives We examined B10 cells in patients with psoriasis and healthy controls. Methods
Peripheral blood mononuclear cells were isolated from psoriasis patients without a history of …
shown to ameliorate psoriasis in mice. Human B10 progenitor cells are characterized as
CD19+ CD24 hi CD38 hi B cells that exert their regulatory functions via the production of IL-
10. However, the role of B10 cells in the pathogenesis of psoriasis remains unclear.
Objectives We examined B10 cells in patients with psoriasis and healthy controls. Methods
Peripheral blood mononuclear cells were isolated from psoriasis patients without a history of …