[HTML][HTML] 5, 6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by …
D Prantner, DJ Perkins, W Lai, MS Williams… - Journal of Biological …, 2012 - ASBMB
The chemotherapeutic agent 5, 6-dimethylxanthenone-4-acetic acid (DMXAA) is a potent
inducer of type I IFNs and other cytokines. This ability is essential for its chemotherapeutic
benefit in a mouse cancer model and suggests that it might also be useful as an antiviral
agent. However, the mechanism underlying DMXAA-induced type I IFNs, including the host
proteins involved, remains unclear. Recently, it was reported that the antioxidant N-
acetylcysteine (NAC) decreased DMXAA-induced TNF-α and IL-6, suggesting that oxidative …
inducer of type I IFNs and other cytokines. This ability is essential for its chemotherapeutic
benefit in a mouse cancer model and suggests that it might also be useful as an antiviral
agent. However, the mechanism underlying DMXAA-induced type I IFNs, including the host
proteins involved, remains unclear. Recently, it was reported that the antioxidant N-
acetylcysteine (NAC) decreased DMXAA-induced TNF-α and IL-6, suggesting that oxidative …