Molecular mechanisms of glomerular injury in rat experimental membranous nephropathy (Heymann nephritis)

D Kerjaschki, TJ Neale - Journal of the American Society of …, 1996 - journals.lww.com
The molecular pathogenesis of human membranous nephropathy (MN) is unknown, despite
the relatively high incidence and severity of this glomerular immune disease. Heymann
nephritis (HN) in rats is considered an instructive experimental model of MN. This study
summarizes current molecular aspects of two key events common to both MN and HN, ie,
formation of characteristic subepithelial immune deposits in the glomerular basement
membrane (GBM), and development of glomerular capillary wall damage resulting in …