[HTML][HTML] Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems
Thioredoxin (Trx) and GSH are the major thiol antioxidants protecting cells from oxidative
stress-induced cytotoxicity. Redox states of Trx and GSH have been used as indicators of
oxidative stress. Accumulating studies suggest that Trx and GSH redox systems regulate cell
signaling and metabolic pathways differently and independently during diverse stressful
conditions. In the current study, we used a mass spectrometry-based redox proteomics
approach to test responses of the cysteine (Cys) proteome to selective disruption of the Trx …
stress-induced cytotoxicity. Redox states of Trx and GSH have been used as indicators of
oxidative stress. Accumulating studies suggest that Trx and GSH redox systems regulate cell
signaling and metabolic pathways differently and independently during diverse stressful
conditions. In the current study, we used a mass spectrometry-based redox proteomics
approach to test responses of the cysteine (Cys) proteome to selective disruption of the Trx …