Toremifene decreases vertebral fractures in men younger than 80 years receiving androgen deprivation therapy for prostate cancer
MR Smith, SB Malkowicz, MK Brawer, ML Hancock… - The Journal of …, 2011 - Elsevier
PURPOSE: Androgen deprivation therapy is associated with an increased fracture risk. In a
recent phase III trial toremifene significantly decreased vertebral fractures in men on
androgen deprivation therapy. Similar to other selective estrogen receptor modulators,
toremifene was associated with an increase in venous thromboembolic events with the
greatest risk in men 80 years old or older. In this post hoc analysis we evaluated the efficacy
and safety of toremifene in men younger than 80 years. MATERIALS AND METHODS: This …
recent phase III trial toremifene significantly decreased vertebral fractures in men on
androgen deprivation therapy. Similar to other selective estrogen receptor modulators,
toremifene was associated with an increase in venous thromboembolic events with the
greatest risk in men 80 years old or older. In this post hoc analysis we evaluated the efficacy
and safety of toremifene in men younger than 80 years. MATERIALS AND METHODS: This …