[HTML][HTML] Primary and secondary agonists can use P2X1 receptors as a major pathway to increase intracellular Ca2+ in the human platelet
CYE Fung, C Cendana, RW Farndale… - Journal of Thrombosis …, 2007 - Elsevier
In the platelet, it is well established that many G‐protein‐and tyrosine kinase‐coupled
receptors stimulate phospholipase‐C‐dependent Ca 2+ mobilization; however, the extent to
which secondary activation of adenosine 5′‐triphosphate (ATP)‐gated P2X 1 receptors
contributes to intracellular Ca 2+ responses remains unclear. We now show that selective
inhibition of P2X 1 receptors substantially reduces the [Ca 2+] i increase evoked by several
important agonists in human platelets; for collagen, thromboxane A 2, thrombin, and …
receptors stimulate phospholipase‐C‐dependent Ca 2+ mobilization; however, the extent to
which secondary activation of adenosine 5′‐triphosphate (ATP)‐gated P2X 1 receptors
contributes to intracellular Ca 2+ responses remains unclear. We now show that selective
inhibition of P2X 1 receptors substantially reduces the [Ca 2+] i increase evoked by several
important agonists in human platelets; for collagen, thromboxane A 2, thrombin, and …
