Hepatocyte transplantation improves the survival of laboratory animals with experimentally
induced acute liver failure and the physiological abnormalities associated with liver-based
metabolic deficiencies. The role of hepatocyte transplantation in treating decompensated
liver cirrhosis, however, has not been studied in depth. To address this issue, cirrhosis was
induced using phenobarbital and carbon tetrachloride (CCL 4) and animals were studied
only when evidence of liver failure did not improve when CCL 4 was held for 4 weeks …