Herpes simplex virus antiviral drug resistance—current trends and future prospects
HJ Field - Journal of Clinical Virology, 2001 - Elsevier
The various manifestations of herpes simplex virus (HSV) have been widely treated using
antiviral agents for more than 40 years. Acyclovir (ACV) is the drug that has been most
commonly used to date. When tested in cell culture, the majority of isolates of HSV are
sensitive to ACV with ED50 values of approximately 0.1 μg/ml. ACV-resistant strains
(defined as having ED50> 2 μg/ml) are rarely encountered in clinical practice among normal
patients (< 1% isolates) and there is no firm evidence, to date, that this incidence is …
antiviral agents for more than 40 years. Acyclovir (ACV) is the drug that has been most
commonly used to date. When tested in cell culture, the majority of isolates of HSV are
sensitive to ACV with ED50 values of approximately 0.1 μg/ml. ACV-resistant strains
(defined as having ED50> 2 μg/ml) are rarely encountered in clinical practice among normal
patients (< 1% isolates) and there is no firm evidence, to date, that this incidence is …