X chromosome-linked muscular dystrophy (mdx) in the mouse.
G Bulfield, WG Siller, PA Wight… - Proceedings of the …, 1984 - National Acad Sciences
G Bulfield, WG Siller, PA Wight, KJ Moore
Proceedings of the National Academy of Sciences, 1984•National Acad SciencesAn X chromosome-linked mouse mutant (gene symbol, mdx) has been found that has
elevated plasma levels of muscle creatine kinase and pyruvate kinase and exhibits
histological lesions characteristic of muscular dystrophy. The mutants show mild clinical
symptoms and are viable and fertile. Linkage analysis with four X chromosome loci indicates
that mdx maps in the Hq Bpa region of the mouse X chromosome. This gives a gene order of
mdx-Tfm-Pgk-1-Ags, the same as for the equivalent genes on the human X chromosome.
elevated plasma levels of muscle creatine kinase and pyruvate kinase and exhibits
histological lesions characteristic of muscular dystrophy. The mutants show mild clinical
symptoms and are viable and fertile. Linkage analysis with four X chromosome loci indicates
that mdx maps in the Hq Bpa region of the mouse X chromosome. This gives a gene order of
mdx-Tfm-Pgk-1-Ags, the same as for the equivalent genes on the human X chromosome.
An X chromosome-linked mouse mutant (gene symbol, mdx) has been found that has elevated plasma levels of muscle creatine kinase and pyruvate kinase and exhibits histological lesions characteristic of muscular dystrophy. The mutants show mild clinical symptoms and are viable and fertile. Linkage analysis with four X chromosome loci indicates that mdx maps in the Hq Bpa region of the mouse X chromosome. This gives a gene order of mdx-Tfm-Pgk-1-Ags, the same as for the equivalent genes on the human X chromosome.
National Acad Sciences