[HTML][HTML] IFN‐γ prevents early perforin‐granzyme‐mediated destruction of kidney allografts by inducing donor class I products in the kidney
B Sis, KS Famulski, KL Allanach, LF Zhu… - American Journal of …, 2007 - Elsevier
Interferon‐γ (Ifng) protects organ allografts: mouse kidney allografts lacking Ifng receptors
rapidly fail with massive ischemic necrosis around days 5 to 7, reflecting microcirculation
failure. We hypothesized that Ifng protects the graft by preventing perforin‐granzyme‐
mediated cytotoxic damage to the microcirculation by inducing class Ia and/or Ib products.
We transplanted kidney allografts lacking Ifng receptors into various knockout hosts. The
necrosis/congestion phenotype did not require host B cells or IL‐4 and IL‐13 receptors, but …
rapidly fail with massive ischemic necrosis around days 5 to 7, reflecting microcirculation
failure. We hypothesized that Ifng protects the graft by preventing perforin‐granzyme‐
mediated cytotoxic damage to the microcirculation by inducing class Ia and/or Ib products.
We transplanted kidney allografts lacking Ifng receptors into various knockout hosts. The
necrosis/congestion phenotype did not require host B cells or IL‐4 and IL‐13 receptors, but …
