Contemporary approaches to treatment of beta-thalassemia intermedia
AT Taher, KM Musallam, M Karimi, MD Cappellini - Blood reviews, 2012 - Elsevier
Beta-thalassemia intermedia (TI) is associated with a variety of serious clinical complications
that require proactive and comprehensive management. These include skeletal deformities
and osteopenia, compensatory extramedullary hematopoiesis and tumor formation,
progressive splenomegaly, a hypercoagulable state resulting in thromboembolic events and
pulmonary hypertension, and increased gastrointestinal iron absorption that often results in
nontransfusional iron overload and liver damage. Although TI is generally considered a non …
that require proactive and comprehensive management. These include skeletal deformities
and osteopenia, compensatory extramedullary hematopoiesis and tumor formation,
progressive splenomegaly, a hypercoagulable state resulting in thromboembolic events and
pulmonary hypertension, and increased gastrointestinal iron absorption that often results in
nontransfusional iron overload and liver damage. Although TI is generally considered a non …
