Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides
L Funkelstein, M Beinfeld, A Minokadeh, J Zadina… - Neuropeptides, 2010 - Elsevier
Neuropeptides are essential for cell–cell communication in the nervous and neuroendocrine
systems. Production of active neuropeptides requires proteolytic processing of
proneuropeptide precursors in secretory vesicles that produce, store, and release
neuropeptides that regulate physiological functions. This review describes recent findings
indicating the prominent role of cathepsin L in secretory vesicles for production of
neuropeptides from their protein precursors. The role of cathepsin L in neuropeptide …
systems. Production of active neuropeptides requires proteolytic processing of
proneuropeptide precursors in secretory vesicles that produce, store, and release
neuropeptides that regulate physiological functions. This review describes recent findings
indicating the prominent role of cathepsin L in secretory vesicles for production of
neuropeptides from their protein precursors. The role of cathepsin L in neuropeptide …
