Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem
JPT Ward, IF McMurtry - Current opinion in pharmacology, 2009 - Elsevier
Hypoxic pulmonary vasoconstriction (HPV) normally optimises ventilation–perfusion
matching in the lung, but leads to pulmonary hypertension (PH) under conditions of global
hypoxia. The past few years have provided some major advances in our understanding of
this complex phenomenon, but significant controversy remains concerning many of the key
underlying mechanisms. On balance, recent evidence is most consistent with an elevation in
mitochondria-derived reactive oxygen species as a key event for initiation of HPV, with …
matching in the lung, but leads to pulmonary hypertension (PH) under conditions of global
hypoxia. The past few years have provided some major advances in our understanding of
this complex phenomenon, but significant controversy remains concerning many of the key
underlying mechanisms. On balance, recent evidence is most consistent with an elevation in
mitochondria-derived reactive oxygen species as a key event for initiation of HPV, with …