Results

Sperman's correlation showed negative association between serum TSH and urinary Dpd (p< 0.021) and borderline, but not significant negative correlation between TSH and ICTP (p< 0.064). However, no correlation was found between TSH and serum PICP. In addition, no correlation was found between FT4 and such parameters of bone remodeling. Expected positive association between serum IGF-I and DHEAS (p< 0.000), between body mass index (BMI) and serum DHEAS (p< 0.015) and negative correlation between BMI and SHGB (p< 0.002) were confirmed. Moreover, negative correlation was found between bone mineral density at the hip and serum SHBG levels (p< 0.000) and positive correlation between BMD at the hip and DHEAS level (p< 0.003). Additionally, 36.5% variability in TSH levels and 30.5% variability in FT4 in our cohort shared with the factor TSH and bone remodeling (factor analysis).

Conclusion

This cross-sectional study suggested negative association between serum TSH and markers of bone resorption in postmenopausal women. It also confirmed the well known mutual interrelations between BMD at the hip and a number of hormonal indices. Although our results did not provide any evidence on the effect of serum TSH and/or SHBG and DHEAS on bone metabolism, they showed some predictive value of these parameters to bone health.