Multipotent adipose stromal cells and breast cancer development: Think globally, act locally
M Zhao, CI Dumur, SE Holt, MJ Beckman… - Molecular …, 2010 - Wiley Online Library
M Zhao, CI Dumur, SE Holt, MJ Beckman, LW Elmore
Molecular carcinogenesis, 2010•Wiley Online LibraryIt has long been appreciated that stromal cells within the breast tumor microenvironment
contribute to mammary carcinogenesis. However, to date, very little is known regarding the
role of local adipose‐derived stromal cells (ASCs) in the development of breast cancer.
Based on pathological, epidemiological and experimental data, we postulate that breast‐
derived ASCs are unique mesenchymal stem‐like cells that play a critical role in the
development of breast cancer and discuss the global implications of this working model in …
contribute to mammary carcinogenesis. However, to date, very little is known regarding the
role of local adipose‐derived stromal cells (ASCs) in the development of breast cancer.
Based on pathological, epidemiological and experimental data, we postulate that breast‐
derived ASCs are unique mesenchymal stem‐like cells that play a critical role in the
development of breast cancer and discuss the global implications of this working model in …
Abstract
It has long been appreciated that stromal cells within the breast tumor microenvironment contribute to mammary carcinogenesis. However, to date, very little is known regarding the role of local adipose‐derived stromal cells (ASCs) in the development of breast cancer. Based on pathological, epidemiological and experimental data, we postulate that breast‐derived ASCs are unique mesenchymal stem‐like cells that play a critical role in the development of breast cancer and discuss the global implications of this working model in terms of breast cancer prevention, early detection, and new targeted therapies. Mol. Carcinog. © 2010 Wiley‐Liss, Inc.
Wiley Online Library