To the Editor Patocs et al.(Dec. 20, 2007, issue) 1 report a frequency of TP53 mutations in
fibroblasts associated with sporadic breast carcinoma of 27.4%, and they show that mutation
status is associated with regional nodal metastasis. If confirmed, this finding would represent
an important discovery. We sought to confirm their findings by direct sequencing of exons 4
through 9 of TP53 in microdissected areas of stroma (< 5 mm from the epithelial cancer
interface) from 10 fresh-frozen sporadic breast-cancer specimens and 7 primary breast …

Breast-cancer stromal cells with TP53 mutations. - Abstract - Europe PMC Sign in | Create an
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