[HTML][HTML] Kruppel-like factor 2 inhibits hypoxia-inducible factor 1α expression and function in the endothelium
D Kawanami, GH Mahabeleshwar, Z Lin… - Journal of Biological …, 2009 - ASBMB
Hypoxia-inducible factor 1 (HIF-1) is a central regulator of the hypoxic response in many cell
types. In endothelial cells, HIF-1 induces the expression of key proangiogenic factors to
promote angiogenesis. Recent studies have identified Kruppel-like factor 2 (KLF2) as a
potent inhibitor of angiogenesis. However, the role of KLF2 in regulating HIF-1 expression
and function has not been evaluated. KLF2 expression was induced acutely by hypoxia in
endothelial cells. Adenoviral overexpression of KLF2 inhibited hypoxia-induced expression …
types. In endothelial cells, HIF-1 induces the expression of key proangiogenic factors to
promote angiogenesis. Recent studies have identified Kruppel-like factor 2 (KLF2) as a
potent inhibitor of angiogenesis. However, the role of KLF2 in regulating HIF-1 expression
and function has not been evaluated. KLF2 expression was induced acutely by hypoxia in
endothelial cells. Adenoviral overexpression of KLF2 inhibited hypoxia-induced expression …