How the immune system achieves self–nonself discrimination during adaptive immunity
H Jiang, L Chess - Advances in immunology, 2009 - Elsevier
Abstract We propose an “Avidity Model of Self–Nonself Discrimination” in which self–nonself
discrimination is achieved by both central thymic selection and peripheral immune
regulation. The conceptual framework that links these two events is the understanding that
both in the thymus and in the periphery the survival or the fate of T cells is determined by the
avidity of the interactions between T cell receptors (TCRs) on T cells, specific to any antigens
and MHC/antigen peptides presented by antigen‐presenting cells (APCs). We envision that …
discrimination is achieved by both central thymic selection and peripheral immune
regulation. The conceptual framework that links these two events is the understanding that
both in the thymus and in the periphery the survival or the fate of T cells is determined by the
avidity of the interactions between T cell receptors (TCRs) on T cells, specific to any antigens
and MHC/antigen peptides presented by antigen‐presenting cells (APCs). We envision that …