Reciprocal regulation via protein-protein interaction between c-Myc and p21 cip1/waf1/sdi1 in DNA replication and transcription
H Kitaura, M Shinshi, Y Uchikoshi, T Ono… - Journal of Biological …, 2000 - ASBMB
The c-myc protooncogene product (c-Myc) is a transcription factor and is rapidly induced in
resting cells following various mitogenic stimuli. c-Myc is thus suggested to play an important
role in the transition from quiescence to proliferation. Despite numerous studies, including
those on the connection between cyclin E/cyclin-dependent kinase 2 and c-Myc, little has
been clarified about c-Myc in terms of the cell cycle regulation. Here we show that c-Myc can
directly bind to the carboxyl-terminal region of the cyclin-dependent kinase inhibitor p21 …
resting cells following various mitogenic stimuli. c-Myc is thus suggested to play an important
role in the transition from quiescence to proliferation. Despite numerous studies, including
those on the connection between cyclin E/cyclin-dependent kinase 2 and c-Myc, little has
been clarified about c-Myc in terms of the cell cycle regulation. Here we show that c-Myc can
directly bind to the carboxyl-terminal region of the cyclin-dependent kinase inhibitor p21 …
