Role of IGF-1 in glucose regulation and cardiovascular disease
A Abbas, PJ Grant, MT Kearney - Expert review of cardiovascular …, 2008 - Taylor & Francis
A Abbas, PJ Grant, MT Kearney
Expert review of cardiovascular therapy, 2008•Taylor & FrancisIGF-1 is a peptide hormone that is expressed in most tissues. It shares significant structural
and functional similarities with insulin, and is implicated in the pathogenesis of insulin
resistance and cardiovascular disease. Recombinant human IGF-1 has been used in Type 2
diabetes to improve insulin sensitivity and aid glycemic control. There is evidence
supporting IGF-1 as a vascular protective factor and it may also be beneficial in the treatment
of chronic heart failure. Further understanding of the effects of IGF-1 signaling in health and …
and functional similarities with insulin, and is implicated in the pathogenesis of insulin
resistance and cardiovascular disease. Recombinant human IGF-1 has been used in Type 2
diabetes to improve insulin sensitivity and aid glycemic control. There is evidence
supporting IGF-1 as a vascular protective factor and it may also be beneficial in the treatment
of chronic heart failure. Further understanding of the effects of IGF-1 signaling in health and …
IGF-1 is a peptide hormone that is expressed in most tissues. It shares significant structural and functional similarities with insulin, and is implicated in the pathogenesis of insulin resistance and cardiovascular disease. Recombinant human IGF-1 has been used in Type 2 diabetes to improve insulin sensitivity and aid glycemic control. There is evidence supporting IGF-1 as a vascular protective factor and it may also be beneficial in the treatment of chronic heart failure. Further understanding of the effects of IGF-1 signaling in health and disease may lead to novel approaches to the prevention and treatment of diabetes and cardiovascular disease.
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