[HTML][HTML] Significance of the transcription factor KLF5 in cardiovascular remodeling
R Nagai, T Suzuki, K Aizawa, T Shindo… - Journal of Thrombosis and …, 2005 - Elsevier
Structural remodeling of the heart and blood vessels is an important pathologic process in
the development of many cardiovascular diseases. However, transcriptional regulation of
altered gene expression during cardiovascular remodeling is not well understood. We
previously isolated KLF5/basic transcription element‐binding (BTEB) 2, a Krüppel‐like
factor, as a transcription factor that binds the promoter of the embryonic smooth muscle
myosin heavy chain gene (SMemb). KLF5 activates many genes inducible during …
the development of many cardiovascular diseases. However, transcriptional regulation of
altered gene expression during cardiovascular remodeling is not well understood. We
previously isolated KLF5/basic transcription element‐binding (BTEB) 2, a Krüppel‐like
factor, as a transcription factor that binds the promoter of the embryonic smooth muscle
myosin heavy chain gene (SMemb). KLF5 activates many genes inducible during …