Regulation of tissue oxygen homeostasis is critical for cell function, proliferation and
survival. Evidence for this continues to accumulate along with our understanding of the
complex oxygen-sensing pathways present within cells. Several pathophysiological
disorders are associated with a loss in oxygen homeostasis, including heart disease, stroke,
and cancer. The microenvironment of tumors in particular is very oxygen heterogeneous,
which may explain much of our difficulty in treating cancer effectively. This is true when …