[HTML][HTML] Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine-and integrin-mediated signals
H Takizawa, K Eto, A Yoshikawa, H Nakauchi… - Experimental …, 2008 - Elsevier
OBJECTIVE: Various cytokines and growth factors control the differentiation and maturation
of megakaryocytes (MKs). However, the mechanism regulating platelet release from MKs is
not well understood. Here, we investigated a role of Lnk/Sh2b3, an intracellular adaptor
protein, in megakaryopoiesis. MATERIALS AND METHODS: Number of MK progenitor in
bone marrow (BM) of wild-type or Lnk−/− mice and their sensitivity to thrombopoietin (TPO)
were determined in colony-forming unit assay. Using BM-derived wild-type or Lnk−/− MKs …
of megakaryocytes (MKs). However, the mechanism regulating platelet release from MKs is
not well understood. Here, we investigated a role of Lnk/Sh2b3, an intracellular adaptor
protein, in megakaryopoiesis. MATERIALS AND METHODS: Number of MK progenitor in
bone marrow (BM) of wild-type or Lnk−/− mice and their sensitivity to thrombopoietin (TPO)
were determined in colony-forming unit assay. Using BM-derived wild-type or Lnk−/− MKs …