[HTML][HTML] Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor
T Criswell, M Beman, S Araki, K Leskov… - Journal of Biological …, 2005 - ASBMB
Secretory clusterin protein (sCLU) is a general genotoxic stress-induced, pro-survival gene
product implicated in aging, obesity, heart disease, and cancer. However, the regulatory
signal transduction processes that control sCLU expression remain undefined. Here, we
report that induction of sCLU is delayed, peaking 72 h after low doses of ionizing radiation,
and is dependent on the up-regulation of insulin-like growth factor-1 as well as
phosphorylation-dependent activation of its receptor (IGF-1 and IGF-1R, respectively) …
product implicated in aging, obesity, heart disease, and cancer. However, the regulatory
signal transduction processes that control sCLU expression remain undefined. Here, we
report that induction of sCLU is delayed, peaking 72 h after low doses of ionizing radiation,
and is dependent on the up-regulation of insulin-like growth factor-1 as well as
phosphorylation-dependent activation of its receptor (IGF-1 and IGF-1R, respectively) …