[HTML][HTML] Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle
V Sauzeau, H Le Jeune, C Cario-Toumaniantz… - Journal of Biological …, 2000 - ASBMB
The potent vasodilator action of cyclic GMP-dependent protein kinase (cGK) involves
decreasing the Ca 2+ sensitivity of contraction of smooth muscle via stimulation of myosin
light chain phosphatase through unknown mechanisms (Wu, X., Somlyo, AV, and Somlyo,
AP (1996) Biochem. Biophys. Res. Commun. 220, 658–663). Myosin light chain
phosphatase activity is controlled by the small GTPase RhoA and its target Rho kinase. Here
we demonstrate cGMP effects mediated by cGK that inhibit RhoA-dependent Ca 2+ …
decreasing the Ca 2+ sensitivity of contraction of smooth muscle via stimulation of myosin
light chain phosphatase through unknown mechanisms (Wu, X., Somlyo, AV, and Somlyo,
AP (1996) Biochem. Biophys. Res. Commun. 220, 658–663). Myosin light chain
phosphatase activity is controlled by the small GTPase RhoA and its target Rho kinase. Here
we demonstrate cGMP effects mediated by cGK that inhibit RhoA-dependent Ca 2+ …
