[HTML][HTML] Transcriptional activity of the ΔNp63 promoter is regulated by STAT3
WK Chu, PM Dai, HL Li, JK Chen - Journal of biological chemistry, 2008 - ASBMB
The N terminus-truncated splicing variant of TAp63 is known as ΔNp63. ΔNp63 lacks
transactivation function and is thought to antagonize the transcriptional regulation of the p53
and TAp63 target genes. Overexpression of ΔNp63 has been observed in a number of
human cancers, suggesting a role in carcinogenesis. In the present study we present data
showing that the ΔNp63 gene promoter activity is positively regulated by ΔNp63α, and such
positive autoregulation is mediated via activation of STAT3 activity. We show that expression …
transactivation function and is thought to antagonize the transcriptional regulation of the p53
and TAp63 target genes. Overexpression of ΔNp63 has been observed in a number of
human cancers, suggesting a role in carcinogenesis. In the present study we present data
showing that the ΔNp63 gene promoter activity is positively regulated by ΔNp63α, and such
positive autoregulation is mediated via activation of STAT3 activity. We show that expression …