Consequences of Notch-mediated induction of Jagged1
DA Ross, T Kadesch - Experimental cell research, 2004 - Elsevier
DA Ross, T Kadesch
Experimental cell research, 2004•ElsevierNotch signaling is initiated upon contact of cells expressing Notch receptors with those
expressing ligands. While examining the dynamic response of NIH 3T3 cells to cells
expressing the Notch ligand Jagged1, we found that Notch signaling resulted in increased
levels of the ligand Jagged1. Induction of Jagged1 was delayed relative to the generation of
active Notch and dependent on the transcription factor p63. The induced Jagged1 had no
apparent autocrine effects on Notch signaling but could promote signaling in naı̈ve cells …
expressing ligands. While examining the dynamic response of NIH 3T3 cells to cells
expressing the Notch ligand Jagged1, we found that Notch signaling resulted in increased
levels of the ligand Jagged1. Induction of Jagged1 was delayed relative to the generation of
active Notch and dependent on the transcription factor p63. The induced Jagged1 had no
apparent autocrine effects on Notch signaling but could promote signaling in naı̈ve cells …
Notch signaling is initiated upon contact of cells expressing Notch receptors with those expressing ligands. While examining the dynamic response of NIH 3T3 cells to cells expressing the Notch ligand Jagged1, we found that Notch signaling resulted in increased levels of the ligand Jagged1. Induction of Jagged1 was delayed relative to the generation of active Notch and dependent on the transcription factor p63. The induced Jagged1 had no apparent autocrine effects on Notch signaling but could promote signaling in naı̈ve cells. These results describe a mechanism through which Notch signaling can be relayed from cell to cell.
Elsevier