Pilot study of myoblast transfer in the treatment of Becker muscular dystrophy
AM Neumeyer, D Cross, D McKenna-Yasek… - Neurology, 1998 - AAN Enterprises
AM Neumeyer, D Cross, D McKenna-Yasek, A Zawadzka, EP Hoffman, E Pegoraro…
Neurology, 1998•AAN EnterprisesWe evaluated myoblast implantation therapy in three subjects with Becker muscular
dystrophy who received 60 million myoblasts in one tibialis anterior (TA) muscle 2 months
after beginning cyclosporine immunosuppression (5 to 10 mg/kg) that continued for 1 year.
Strength of the implanted and control TA muscles was measured before and after treatment
using a gauge to record TA contraction force. Our protocol controlled for the effects of
cyclosporine and myoblast injections. In this pilot, myoblast implantation did not improve …
dystrophy who received 60 million myoblasts in one tibialis anterior (TA) muscle 2 months
after beginning cyclosporine immunosuppression (5 to 10 mg/kg) that continued for 1 year.
Strength of the implanted and control TA muscles was measured before and after treatment
using a gauge to record TA contraction force. Our protocol controlled for the effects of
cyclosporine and myoblast injections. In this pilot, myoblast implantation did not improve …
We evaluated myoblast implantation therapy in three subjects with Becker muscular dystrophy who received 60 million myoblasts in one tibialis anterior(TA) muscle 2 months after beginning cyclosporine immunosuppression (5 to 10 mg/kg) that continued for 1 year. Strength of the implanted and control TA muscles was measured before and after treatment using a gauge to record TA contraction force. Our protocol controlled for the effects of cyclosporine and myoblast injections. In this pilot, myoblast implantation did not improve strength of the implanted TA muscles.
American Academy of Neurology