BH3-only BIK regulates BAX, BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death
JP Mathai, M Germain, GC Shore - Journal of Biological Chemistry, 2005 - ASBMB
BIK, a pro-apoptotic BH3-only member of the BCL-2 family, targets the membrane of the
endoplasmic reticulum (ER). It is induced in human cells in response to several stress
stimuli, including genotoxic stress (radiation, doxorubicin) and overexpression of E1A or p53
but not by ER stress pathways resulting from protein malfolding. BIK initiates an early
release of Ca 2+ from ER upstream of the activation of effector caspases. Release of the
mobile ER Ca 2+ stores in baby mouse kidney cells doubly deficient in BAX and BAK, on the …
endoplasmic reticulum (ER). It is induced in human cells in response to several stress
stimuli, including genotoxic stress (radiation, doxorubicin) and overexpression of E1A or p53
but not by ER stress pathways resulting from protein malfolding. BIK initiates an early
release of Ca 2+ from ER upstream of the activation of effector caspases. Release of the
mobile ER Ca 2+ stores in baby mouse kidney cells doubly deficient in BAX and BAK, on the …
