Identification of two Melan-A CD4+ T cell epitopes presented by frequently expressed MHC class II alleles
E Godefroy, L Scotto, NE Souleimanian, G Ritter… - Clinical …, 2006 - Elsevier
Because of its expression pattern restricted to cells of the melanocytic lineage and to
melanoma cells, Melan-A is an important target of immunotherapeutic approaches for the
treatment of melanoma. Identification of Melan-A derived sequences recognized by specific
T cells is therefore of great interest for the development of these therapeutic strategies.
Using circulating CD4+ T cells from healthy donors, we identified two Melan-A-derived
CD4+ T cell epitopes mapping to the 1–20 and 91–110 regions of the protein and restricted …
melanoma cells, Melan-A is an important target of immunotherapeutic approaches for the
treatment of melanoma. Identification of Melan-A derived sequences recognized by specific
T cells is therefore of great interest for the development of these therapeutic strategies.
Using circulating CD4+ T cells from healthy donors, we identified two Melan-A-derived
CD4+ T cell epitopes mapping to the 1–20 and 91–110 regions of the protein and restricted …