Myeloperoxidase: an inflammatory enzyme for generating dysfunctional high density lipoprotein
Oxidation of HDL by myeloperoxidase may represent a specific molecular mechanism for
converting the cardioprotective lipoprotein into a dysfunctional form, raising the possibility
that the enzyme represents a potential therapeutic target for preventing vascular disease in
humans. Moreover, oxidized HDL might prove useful as a blood marker for clinically
significant cardiovascular disease in humans.
converting the cardioprotective lipoprotein into a dysfunctional form, raising the possibility
that the enzyme represents a potential therapeutic target for preventing vascular disease in
humans. Moreover, oxidized HDL might prove useful as a blood marker for clinically
significant cardiovascular disease in humans.
Summary
Oxidation of HDL by myeloperoxidase may represent a specific molecular mechanism for converting the cardioprotective lipoprotein into a dysfunctional form, raising the possibility that the enzyme represents a potential therapeutic target for preventing vascular disease in humans. Moreover, oxidized HDL might prove useful as a blood marker for clinically significant cardiovascular disease in humans.
Lippincott Williams & Wilkins