[HTML][HTML] Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and …
IC Schoenhofen, DJ McNally, E Vinogradov… - Journal of Biological …, 2006 - ASBMB
Helicobacter pylori and Campylobacter jejuni have been shown to modify their flagellins
with pseudaminic acid (Pse), via O-linkage, while C. jejuni also possesses a general protein
glycosylation pathway (Pgl) responsible for the N-linked modification of at least 30 proteins
with a heptasaccharide containing 2, 4-diacetamido-2, 4, 6-trideoxy-α-d-glucopyranose, a
derivative of bacillosamine. To further define the Pse and bacillosamine biosynthetic
pathways, we have undertaken functional characterization of UDP-α-d-GlcNAc modifying …
with pseudaminic acid (Pse), via O-linkage, while C. jejuni also possesses a general protein
glycosylation pathway (Pgl) responsible for the N-linked modification of at least 30 proteins
with a heptasaccharide containing 2, 4-diacetamido-2, 4, 6-trideoxy-α-d-glucopyranose, a
derivative of bacillosamine. To further define the Pse and bacillosamine biosynthetic
pathways, we have undertaken functional characterization of UDP-α-d-GlcNAc modifying …