[HTML][HTML] Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production …
Mannose-capped lipoarabinomannans (Man-LAMs) are members of the repertoire of
Mycobacterium tuberculosis modulins that the bacillus uses to subvert the host innate
immune response. Interleukin-12 (IL-12) production is critical for mounting an effective
immune response by the host against M. tuberculosis. We demonstrate that Man-LAM
inhibits IL-12 p40 production mediated by subsequent challenge with lipopolysaccharide
(LPS). Man-LAM inhibits LPS-induced IL-12 p40 expression in an IL-10-independent …
Mycobacterium tuberculosis modulins that the bacillus uses to subvert the host innate
immune response. Interleukin-12 (IL-12) production is critical for mounting an effective
immune response by the host against M. tuberculosis. We demonstrate that Man-LAM
inhibits IL-12 p40 production mediated by subsequent challenge with lipopolysaccharide
(LPS). Man-LAM inhibits LPS-induced IL-12 p40 expression in an IL-10-independent …
