Clinical implications of expression of interleukin 8 related to angiogenesis in uterine cervical cancers
J Fujimoto, H Sakaguchi, I Aoki, T Tamaya - Cancer research, 2000 - AACR
J Fujimoto, H Sakaguchi, I Aoki, T Tamaya
Cancer research, 2000•AACRThere was a significant correlation between microvessel counts and interleukin (IL)-8 levels
and between infiltrated macrophage counts and IL-8 levels in uterine cervical cancers.
Immunohistochemical staining revealed that the localization of IL-8 was similar to that of
CD68 for macrophages. The prognosis of the 20 patients with high IL-8 (> 1000 pg/mg
protein) in uterine cervical cancers was extremely poor, whereas the 24-month survival rate
of the other 60 patients with low IL-8 (< 1000 pg/mg protein) was 67%. Therefore, this …
and between infiltrated macrophage counts and IL-8 levels in uterine cervical cancers.
Immunohistochemical staining revealed that the localization of IL-8 was similar to that of
CD68 for macrophages. The prognosis of the 20 patients with high IL-8 (> 1000 pg/mg
protein) in uterine cervical cancers was extremely poor, whereas the 24-month survival rate
of the other 60 patients with low IL-8 (< 1000 pg/mg protein) was 67%. Therefore, this …
Abstract
There was a significant correlation between microvessel counts and interleukin (IL)-8 levels and between infiltrated macrophage counts and IL-8 levels in uterine cervical cancers. Immunohistochemical staining revealed that the localization of IL-8 was similar to that of CD68 for macrophages. The prognosis of the 20 patients with high IL-8 (>1000 pg/mg protein) in uterine cervical cancers was extremely poor, whereas the 24-month survival rate of the other 60 patients with low IL-8(<1000 pg/mg protein) was 67%. Therefore, this indicates that IL-8 might be a prognostic indicator as an angiogenic factor supplied from macrophages within and around the tumor.
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